Virology and immunology research at Gladstone is focused primarily on three primary and urgent challenges in HIV/AIDS. We desperately need a vaccine for those at risk of coming in contact with the virus, as well as a cure for the millions of people who are already infected. And finally, we need new approaches for restoring a normal lifespan to those who are HIV-positive—but dying much too early from diseases of aging. In addition to HIV, we’re working on a variety of other areas of investigation: Gladstone scientists are looking for new biological targets for drugs that will attack the hepatitis C virus—which has infected 170 million people worldwide. Hepatitis C is a common co-infection with HIV/AIDS. We are also investigating the molecular structure of viruses associated with cancer—and how to remove them from the body as a way to reduce the risk of cancer. And we are investigating why newborns and infants mount less effective immune responses to viruses than adults do.

Institute of Virology, Technische Universität München / Helmholtz Zentrum München:  Research at the Institute of Virology is geared toward pathogenic human viruses such as hepatitis viruses, HIV, poxviruses or SARS virus.  Their study focuses on molecular details of the viral replication cycle, host-pathogen interactions and the role of immunity in viral diseases. The institute is equipped with state-of-the-art instrumentation, BSL2 and BSL3 laboratories and an immune monitoring unit.  In spring 2013, the Global Virus Network met in Munich to discuss the topics of control of chronic and emerging viral infections. The workshop highlighted the Durability of Vaccine-induced Immune Response, and was led by GVN Co-Founder and International Scientific Advisor, Dr. Robert Gallo and Ulrike Protzer, among other speakers at the event.

Originally founded in 1892, the National Institute of Infectious Diseases aims at carrying out extensive and original research projects on a variety of contagious diseases from the standpoint of preventive medicine, improving human health and welfare by suppressing infectious diseases, and clarifying and supporting the scientific background of health and medical administration of the government. These functions may be summarized into 1) research activities, 2) reference services for infectious diseases, 3) surveillance of infectious diseases, 4) national control tests and other tests, 5) international cooperation, and 6) training activities.

Harare is home to a NIH AIDS Clinical Trials Unit that conducts research with NIAID HIV Research networks including the AIDS Clinical Trials Group (ACTG), International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT), and Microbial Trials Network (MTN). In addition, UZ has a NIAID HIV Clinical Pharmacology Specialty Laboratory. These clinical research networks are led by senior clinical scientists who have been involved in international multicenter trials for the past two decades hence their ability to contribute to the HIV, HBV, HCV, HPV, and other global virology research agendas. A number of NIH funded studies exist including training programs such as e.g., International Clinical, Operational and Health Services Research Training Award for AIDS and TB (ICOHRTA AIDS/TB) as well as the PEPFAR funded Medical Education Partnership Initiative (MEPI).The Antiviral Pharmacology Laboratory was initially funded as a developmental International Pharmacology Specialty Laboratory and in 2015 gained status as an ACTG International Specialty Pharmacology Laboratory. This change in status reflected successful external assessment for its readiness to participate in protocol support for ACTG as well as other networks within the Clinical Trails Unit – Virology Program. The interface among the HIV Research Networks allows the clinical pharmacology laboratory to contribute drug assays, pharmacokinetic, pharmacodynamics, drug interactions and pharmacogenomics research to HIV prevention and treatment research protocols in adults, pediatrics, adolescents, pregnant women, as well as to cure, vaccines, and co-infection (e.g., TB, HBV, HPV) protocols.

Karolinska Institute (KI) is one of the world’s leading medical universities. Their mission is centered toward research and education, to help improve people’s health. In Sweden, Karolinska Institute accounts for over 40 per cent of the medical academic research and has the largest collection of medical education. Since 1901 the Nobel Assembly at Karolinska Institute has selected the Nobel laureates in Physiology or Medicine, and several alumni have won the prestigious award.

The MRC-University of Glasgow Centre for Virus Research (CVR) represents the UK’s largest grouping of human and veterinary virologists. More than 20 principal investigators and their associated teams make up the research core of the CVR creating a critical mass of researchers dedicated to the study of human and animal viral diseases. We carry out multidisciplinary research on viruses and viral diseases, translating the knowledge gained for the improvement of health and benefit of society. Research at the CVR spans molecular, structural and cellular levels through to the individual host and affected population, thus integrating molecular and structural virology, cell biology, pathogenesis, epidemiology and mathematical modelling. Our research covers emerging viruses including arboviruses, innate and intrinsic immunity to virus infection, hepatitis C virus, viruses and cancer, structural virology, viral genomics and bioinformatics.

The University of Texas Medical Branch (UTMB) is known worldwide for its academic excellence in virology research. The scientists and academic staff at the university include some of the world’s foremost infectious disease experts, and research at the university results in groundbreaking biomedical discoveries and the development of vaccines, therapeutics and diagnostic tools. The Galveston National Laboratory (GNL), the flagship high containment facility of the UTMB Institute of Human Infections and Immunity, resides on the UTMB campus and houses research on Ebola, chikungunya, MERS coronavirus, dengue, West Nile, and other emerging viruses. The Institute also includes the Center for Biodefense & Emerging Infectious Diseases, the Sealy Center for Vaccine Development, the Center for Tropical Diseases, and the McLaughlin Endowment for Infection and Immunity.

The Wyss Institute for Biologically Inspired Engineering at Harvard University creates transformative technological breakthroughs by engaging in high-risk research, crossing disciplinary and institutional barriers, to develop new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. Our technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and formation of new startups

The Division of Infectious Diseases at the University of Michigan was founded in 1958. Since then, the division has become recognized nationally for an exemplary record of patient care, research and teaching. In addition to the regular Infectious Diseases Outpatient Service, an Immunization and Overseas Travel Consultation Service is available for consultation, general health advice, and immunizations for both domestic and international travel. The University of Michigan Health System is among the best in the world, ranked in the top 15 health systems in the country in the most recent U.S. News and World Report. The Department of Internal Medicine consists of over 600 full time academic faculty, and is ranked fourth in the country in NIH research dollars.

The University of Wisconsin-Madison (UW-Madison) is world renowned for its research and translational programs in virology and the global reach of these programs.  The UW-Madison Global Health Institute lies at the crossroads of these endeavors and serves as an umbrella organization for broad-based activities on emerging themes in global health.  Virologists at UW-Madison study agents infecting humans, animals, and plants, including highly pathogenic viruses (e.g. the ebolaviruses) and viruses with pandemic potential (e.g. influenza virus, arboviruses).  Activities range from basic research to the development of vaccines and therapeutics to public health and policy.  UW-Madison has particular strengths in emerging viral pathogens and zoonosis, including rapid detection and characterization of viral agents, the development of animal models (especially primates), and the development of countermeasures such as vaccines and therapeutics.